The Carroll Building, commonly referred to as Old South, was the first building erected on the campus of Georgetown University. The building was named for John Carroll, Georgetown's founder and, later, first bishop and archbishop of Baltimore.

Old North is a building on the campus of Georgetown University, located to the west of Healy Hall and forming a right angle with Healy's northern end. Built in 1795, it is the oldest academic building on campus. It was constructed at a cost of $123,230 and comprises 28,666 square feet.

The Georgetown Observatory was built in 1844, making it the fifth oldest building on campus and the third oldest college observatory in the United States (after Williams College and Western Reserve). Brother Joseph West, S.J., donated the land on which it is built to the University when he took his final vows. The building comprises 5,066 square feet and was built under the direction of Father James Curley, S.J.

White-Gravenor Hall, located across the front lawn from Lauinger Library and next to Red Square, currently houses classrooms, offices for the Georgetown College deans, the University Registrar, and the Office of Undergraduate Admissions. 

The Reiss Science Building is an academic building that formerly housed Georgetown's science departments and labs. With the opening of Regents Hall in 2012, Reiss now houses various classrooms.

The Bioethics Research Library is located in Georgetown's Healy Hall and is open to students, faculty, and visiting researchers. It occupies the space once known as the Hirst Library. The Bioethics Research Library first began as just a few shelves collected by the Kennedy Institute of Ethics, but now has the largest collection of books on bioethics and biomedical research, with more than 100,000 volumes.

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