Marcus J. Bles (1905/1906 (?) - January 9, 1986) moved to Northern Virginia in 1941 from Missouri, where he had been a farmer, and established a business in earth-moving equipment where he was involved in the construction of the Pentagon. By the 1950s, his construction firm, M.J. Bles Construction Co., was one of the largest construction companies in Northern Virginia. 

Walter R. Abell, C'1869 (1849 – January 3, 1891) was editor of the Baltimore Sun.

Frank Baker (August 22, 1841 – September 30, 1918) was professor of anatomy at the Georgetown Medical School from 1883 to 1918 and also served as Superintendent of the National Zoo.

Charles O'Brien Cowardin, C'1874 (October 23, 1835 – July 5, 1900) was president of the Richmond Dispatch Company and editor-in-chief of the Richmond Dispatch newspaper.

Joseph Hubley Ashton (March 11, 1836 – March 14, 1907) was a professor in the Georgetown University Law School from 1870 to 1874.

Joseph James Darlington (February 10, 1849- June 24, 1920), was an attorney, author of Darlington on Personal Property, and instructor in the Georgetown University Law School from 1881-1900.

Frank J. Hogan (1877 - 1944) graduated from Georgetown University School of Law in 1902 with an LL. B. degree. He worked at the firm of Sheehy & Hogan in Washington, DC.

Edward Douglass White, Jr. (November 3, 1845 – May 19, 1921) was an alumnus of Georgetown College, a lawyer, politician, and judge.

Francis Kernan (1816 – 1892) was a student at Georgetown College, a lawyer, and politician.

William M. Merrick (1818 - 1889) was a graduate of Georgetown University, a lawyer, politician, judge, and faculty member at Georgetown University Law School. He received two degrees from Georgetown: an A.M. in 1831 and an honorary LL. D. in 1875. He was the son of Hon. William D. Merrick and the sibling of two other Georgetown alumni: Richard Thomas and George Carr Merrick. 

Martin F. Morris (1834 - ?) was a Georgetown alumnus and a lawyer, judge, and professor at Georgetown University Law School. Along with another Georgetown alumnus, Richard T. Merrick, he formed the law firm of Merrick & Morris in 1868.

George Ernest Hamilton (1855 – ?) was an alumnus of Georgetown University, a lawyer, and faculty member of the Law School. He received four degrees from Georgetown: an A.B. in 1872, an LL. B in 1874, an A.M. in 1882, and an honorary LL. D. in 1889.

Dalia Grybauskaitė (1956 – , SFS 1992), is a Lithuanian politician and an alumna of the Georgetown School of Foreign service. She served as the eighth President of Lithuania, from 2009 to 2019. She was the country's first woman president and previously served as its finance minister and as European Union budget commissioner.

Tallmadge Augustine Lambert (1842 - ?) was an alumnus of Georgetown University, a lawyer, and faculty member of the law school. He received his A.B. from Georgetown in 1862 and was the valedictorian of his class.

Lambert was born on December 20, 1842 to Daniel Lambert and Frederica R. (née Preuss) Lambert in Madison, Wisconsin. His family was originally from Connecticut and his ancestors had founded the town of Wilton, Connecticut. 

Pearl Bailey was a popular singer, actress, and ambassador who graduated from Georgetown with a Bachelor's in Theology in 1985, at the age of 67.